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自１９８５年２月至１９９２年８月，我院５１３例接受免疫抑制剂治疗的肾移植，患者中有４例出现恶性肿瘤。以尿路肿瘤，特别是膀胱癌为主，两例死亡，两例远处转移。本文就病因学、临床治疗等进行了探讨。认为导致肾移植患者肿瘤的最关键因素是肿瘤基因病毒在免疫抑制患者的淋巴细胞异常增殖中增生，而＂免疫监护系统＂受到破坏，导致肿瘤的发生。提出减少免疫抑制剂如ＣｓＡ至原量的１／４，彻底清除原发病灶的治疗原则，其中２例患者获得较好的治疗。
From February 1985 to August 1992, 513 patients receiving immunosuppressive therapy in our hospital had kidney transplants, and 4 of the patients had malignant neoplasms. Urinary tract tumors, especially bladder cancer, died of two cases and distant metastases in two cases. This article discusses the etiology, clinical treatment and so on. It is thought that the most crucial factor leading to tumors in kidney transplant patients is that the tumor gene virus proliferates in abnormal proliferation of lymphocytes in immunosuppressed patients, and the “immune monitoring system” is destroyed, resulting in the occurrence of tumors. Proposed to reduce immunosuppressive agents such as CsA to the original 1/4, the principle of complete removal of primary lesions, of which 2 patients get better treatment.