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目的研究甲泼尼龙对小儿原发性肾病综合征患儿尿蛋白及血浆白蛋白水平的影响。方法选取2013年5月至2016年3月本院收治的原发性肾病综合征患儿120例,随机分为2组,对照组及观察组各60例。对照组患儿给予泼尼松片进行治疗,观察组患儿给予甲泼尼龙片,连续治疗2个月,观察2组患儿治疗后临床疗效及尿蛋白、血浆白蛋白水平情况。结果观察组患儿治疗后临床疗效总有效率为91.67%,明显高于对照组的68.33%(P<0.05);观察组患儿治疗后尿蛋白、血浆白蛋白水平值明显优于对照组(P<0.05)。结论甲泼尼龙对小儿原发性肾病综合征患儿尿蛋白及血浆白蛋白水平的影响良好,临床疗效显著,值得临床推广。
Objective To investigate the effect of methylprednisolone on urinary protein and plasma albumin in children with primary nephrotic syndrome. Methods 120 cases of primary nephrotic syndrome admitted to our hospital from May 2013 to March 2016 were randomly divided into two groups, 60 cases in control group and observation group. Children in the control group were given prednisone tablets. Methylprednisolone tablets were given to the observation group for 2 months. The clinical efficacy, urinary protein and plasma albumin levels were observed after treatment in both groups. Results The total effective rate of the treatment group was 91.67%, significantly higher than that of the control group (68.33%, P <0.05). The urinary albumin and plasma albumin levels of the observation group were significantly better than those of the control group P <0.05). Conclusion Methylprednisolone has a good effect on urinary protein and plasma albumin in children with primary nephrotic syndrome, and its clinical curative effect is significant. It is worthy of clinical promotion.