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四氧嘧啶性糖尿病大鼠,血清总胆固醇(TC)、胆固醇酯(CE)、高密度脂蛋白-胆固醇(HDL-C)和低密度脂蛋白-胆固醇(LDL-C)较对照均显著上升,但极低密度脂蛋白-胆固醇(VLDL-C)和HDL-C/LDL-C则没有差别。影响血清高密度脂蛋白(HDL)水平的几个因素测定结果为脂蛋白脂酶(LPL)和肝内皮细胞脂酶(HEL)及肝细胞对~(125)I-HDL的吸收和分解能力显著低于对照;卵磷脂胆固醇酰基转移酶(LCAT)活性和肝灌流液中HDL-C水平显著上升。 可见糖尿病大鼠由于体内胰岛素绝对缺乏可通过以下几个方面影响HDL和胆固醇代谢:降低肝细胞对HDL的吸收和分解;促进肝脏分泌HDL;抑制HEL和LPL的活性;升高LCAT活性;升高血清TC、CE、HDL-C和LDL-C水平,而对VLDL-C及HDD-C/LDL-C没有影响。
Compared with the control group, alloxan-induced diabetic rats had significantly higher serum TC, CE, HDL-C and LDL-C, However, there was no difference between very low density lipoprotein-cholesterol (VLDL-C) and HDL-C / LDL-C. Several factors influencing the level of serum high density lipoprotein (HDL) were determined by the ability of lipoprotein lipase (LPL) and hepatocyte lipase (HEL) and hepatocytes to absorb and decompose 125 I-HDL Lower than the control; lecithin cholesterol acyltransferase (LCAT) activity and HDL-C levels in liver perfusion fluid increased significantly. It can be seen that due to the absolute lack of insulin in diabetic rats, HDL and cholesterol metabolism can be affected by the following aspects: reducing the absorption and decomposition of HDL by hepatocytes; promoting the secretion of HDL by the liver; inhibiting the activity of HEL and LPL; increasing the activity of LCAT; Serum TC, CE, HDL-C and LDL-C levels had no effect on VLDL-C and HDD-C / LDL-C.