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癌干细胞在肿瘤的发生、发展、转移和术后复发中所起的作用越来越受到重视,分离和富集癌干细胞有助于确定参与肿瘤生长、复发和转移的触发器。近年来,更多研究者的目光聚焦于研究癌干细胞机制这一点上。笔者对癌干细胞分离、富集常规和新兴的手段,以及肿瘤与微环境之间的相互作用机制进行综述,旨在为肿瘤发展研究及寻求新的治疗方法提供理论依据。
Cancer stem cells play a more and more important role in tumorigenesis, development, metastasis and postoperative recurrence. Isolating and enriching cancer stem cells helps to identify triggers involved in tumor growth, recurrence and metastasis. In recent years, more researchers have focused their attention on the research of cancer stem cell mechanism. The author summarizes the mechanism of cancer stem cells separation, enrichment of routine and emerging, and the interaction between tumor and microenvironment, aiming to provide a theoretical basis for the study of tumor development and the search for new treatment methods.