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本文对对氨基水杨酸钠(Ⅰ)片的处方及工艺进行了研究。处方Ⅰ0.5 g,蔗糖0.0089 g,焦亚硫酸钠0.005 g,甲基纤维素0.0015 g,硬脂酸0.0046 g(总重0.52 g)。制片工艺将粉碎过筛的Ⅰ与蔗糖和焦亚硫酸钠混合,以5%甲基纤维素溶液润湿制成软材,置50～60℃烘箱内干燥至最佳湿度为16～17%。干燥物经孔径1mm筛网,压成平均片重0.52 g、直径11mm的片剂。硬度40～50N,崩解5～6分钟。本研究采用火焰光度法测定体液中Ⅰ浓度。此法可在不含钠离子的各种混合物中测出Ⅰ。实验用18只2.5～3 kg的家兔,片剂
In this paper, the prescription of sodium aminosalicylate (Ⅰ) tablets and the process were studied. Prescription I 0.5 g, sucrose 0.0089 g, sodium metabisulfite 0.005 g, methylcellulose 0.0015 g, stearic acid 0.0046 g (total weight 0.52 g). Production process will smash sieved Ⅰ and sucrose and sodium metabisulfite mixed with 5% methyl cellulose solution wetting made of soft material, set at 50 ~ 60 ℃ oven dried to an optimum humidity of 16 to 17%. The dried material was passed through a 1 mm mesh screen and pressed into tablets having an average tablet weight of 0.52 g and a diameter of 11 mm. Hardness 40 ~ 50N, disintegration 5 to 6 minutes. In this study, the concentration of Ⅰ in body fluid was determined by flame photometry. This method can be measured in various mixtures without sodium ions Ⅰ. Experiment with 18 2.5 ~ 3 kg of rabbits, tablets