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奥沙普嗪((口恶)丙嗪,oxaprozin,OXP)是一种新的非甾体抗炎、镇痛、解热药物,最早由英国Wyeth公司研制开发,1993年美国FDA批准奥沙普嗪为第一个1天1次给药的长效消炎镇痛药。近年来该药经我国卫生部审查,作为二类新药在全国生产销售。现将该药的药理作用及临床应用概述如下: 1 药理作用 1.1 药效学 ①作用机制 前列腺素是引起炎症和疼痛的内源性介质,奥沙普嗪与其它非甾体药物一样,主要通过抑制环氧化酶(cyclooxygenasc,Cox)即减少由花生四烯酸代谢产生的前列腺素的合成而达到抗炎镇痛作用。②作用特点 a长效该药在人体内的消除半衰期50h～60h,在非甾体解热镇痛药物中作用时间最长,因而服药后可以较长时间维持具有治疗水平的血药浓度,因此,每日口服一次就可维持疗效。b副作用小 环氧化酶有两
Oxaprozin (oxaprozin, oxyprozin, OXP) is a new non-steroidal anti-inflammatory, analgesic and antipyretic drug. It was first developed and developed by Wyeth Company in the United Kingdom. In 1993, the United States FDA approved oxaliplatin Zinc is the first long-acting anti-inflammatory analgesic administered once a day. In recent years, the drug has been reviewed by China’s Ministry of Health as a second-class new drug in the country’s production and sales. Now the pharmacological effects and clinical application of the drug are summarized as follows: 1 pharmacological effects 1.1 pharmacodynamics ① mechanism of action Prostaglandin is caused by inflammation and pain of endogenous media, oxaprozin and other non-steroidal drugs, mainly through Inhibition of cyclooxygenase (cyclooxygenase, Cox) that is reduced by the metabolism of arachidonic acid prostaglandin synthesis and achieve anti-inflammatory analgesic effect. The role of a long-acting drug elimination half-life in the human body 50h ~ 60h, the role of non-steroidal antipyretic analgesics in the longest time, and therefore medication can be maintained for a long time with a therapeutic level of plasma concentration, therefore , Oral once a day to maintain efficacy. b Side effects Small cyclooxygenase has two