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目的:综合评价鼠双微体基因2(murine doubleminute 2,MDM2)启动子309位点的单核苷酸多态性(single nucleotide polymorphism,SNP)与非小细胞肺癌易感性的关系。方法:应用计算机检索Cochrane Library、PubMed、EMBase、中国知网、万方和维普等数据库,按照文献纳入标准和排除标准选择研究文献,评价文献质量,并提取资料。采用STATA 12.0软件进行Meta分析,计算MDM2 SNP 309T/G与非小细胞肺癌易感性关系的合并比值比(odds ratio,OR),并进行亚组分析、敏感性分析和发表偏倚检验。结果:最终纳入8项病例对照研究,共包括5 343例患者和6 652例正常对照。Meta分析结果显示,MDM2 SNP 309GG显著增加了非小细胞肺癌的发病风险[TT vs GG,OR=0.77,95%可信区间(confidence interval,CI)=0.62~0.96;GT vs GG,OR=0.83,95%CI=0.75~0.92:TT+GT vs GG,OR=0.82,95%CI=0.75~0.91]。在种族亚组分析中,MDM2 SNP 309GG显著增加了亚洲人群非小细胞肺癌的发病风险[TT vs GG,OR=0.62,95%CI=0.52~0.73;GT vs GG,OR=0.78,95%CI=0.67~0.90:TT vs GG+GT,OR=0.71,95%CI=0.59~0.86;TT+GT vs GG,OR=0.73,95%CI=0.63~0.84]。在性别亚组分析中,MDM2 SNP 309GG显著增加了女性非小细胞肺癌的发病风险[TT vs GG,OR=0.70,95%CI=0.54~0.91;GT vs GG,OR=0.69,95%CI=0.54~0.90;TT+GT vs GG,OR=0.70,95%CI=0.55~0.89]。结论:MDM2 SNP 309GG是非小细胞肺癌易感性增加的危险因素,尤其是对于亚洲人群和女性人群。
Objective: To evaluate the relationship between single nucleotide polymorphism (SNP) at position 309 of murine double minute 2 (MDM2) promoter and susceptibility to non-small cell lung cancer. Methods: The databases of Cochrane Library, PubMed, EMBase, CNKI, Wanfang and Vipu were searched by computer. The research documents were selected according to the inclusion criteria and exclusion criteria, the quality of the literature was evaluated, and the data were extracted. Meta-analysis was performed using STATA 12.0 software to calculate the odds ratio (OR) of MDM2 SNP 309T / G susceptibility to non-small cell lung cancer. Subgroup analyzes, sensitivity analyzes, and published bias tests were also performed. Results: Eight case-control studies were included, including a total of 5 343 patients and 6 652 normal controls. Meta-analysis showed that MDM2 SNP 309GG significantly increased the risk of non-small cell lung cancer (TT vs GG, OR = 0.77, 95% confidence interval (CI) = 0.62-0.96; GT vs GG, OR = 0.83 , 95% CI = 0.75 ~ 0.92: TT + GT vs GG, OR = 0.82, 95% CI = 0.75 ~ 0.91]. In ethnic subgroup analysis, MDM2 SNP 309GG significantly increased the risk of non-small cell lung cancer in Asian populations [TT vs GG (OR = 0.62, 95% CI = 0.52-0.73; GT vs GG, OR = 0.78, 95% CI = 0.67 ~ 0.90: TT vs GG + GT, OR = 0.71, 95% CI = 0.59 ~ 0.86; TT + GT vs GG, OR = 0.73, 95% CI = 0.63 ~ 0.84]. In the subgenomic analysis, MDM2 SNP 309GG significantly increased the risk of developing NSCLC [TT vs GG, OR = 0.70, 95% CI = 0.54-0.91; GT vs GG, OR = 0.69, 95% CI = 0.54 ~ 0.90; TT + GT vs GG, OR = 0.70, 95% CI = 0.55 ~ 0.89]. Conclusion: MDM2 SNP 309GG is a risk factor for increased susceptibility to non-small cell lung cancer, especially in Asian and females.