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目的为了解母亲孕期补钙和维生素D是否影响其生后婴儿骨密度(Bone mineral density,BMD),同时探讨性别、民族、喂养方式、出生季节、早产、母亲年龄等因素与婴儿BMD异常的关系。方法2009年7月～2010年7月在新疆维吾尔自治区人民医院儿童保健门诊进行健康查体的42d婴儿335例,自主设计《婴儿BMD相关因素调查表》,进行相关情况的调查。应用以色列Sunlight公司Omnisense7000型定量超声波BMD测定仪在小儿左或右胫骨做BMD超声检测,采用EXECL2003和SPSS13.0软件进行BMD检测结果数据整理及分析。结果335例42天婴儿中,BMD正常者占45.4%(152/335),偏低者占54.6%(183/335),母亲孕期补钙和维生素D三个月以上者中,其婴儿BMD正常率高于母亲孕期补钙和维生素D三个月以下或未补者的婴儿(P<0.05)。母乳喂养婴儿组BMD偏低率明显低于人工喂养组和混合喂养组(P均<0.05),维吾尔族婴儿BMD偏低率明显低于汉族婴儿(P<0.05);婴儿性别,早产,出生季节,母亲年龄等因素与婴儿BMD检测结果无明显的相关性(P均>0.05)。结论母亲孕期进行补钙和维生素D三个月以上,对生后婴儿BMD维持正常有积极作用。母乳喂养是维持婴儿BMD正常最好的喂养方式。
Objective To investigate whether maternal calcium supplementation and vitamin D affect their postnatal infant Bone mineral density (BMD), and to explore the relationship between gender, ethnicity, feeding patterns, birth season, premature birth and maternal age and BMD abnormalities in infants . Methods From July 2009 to July 2010, 335 children aged 42 days from 42d children’s health clinics of People’s Hospital of People’s Hospital of Xinjiang Uygur Autonomous Region were enrolled in this study. The relevant questionnaire was surveyed. The application of the Omnisense 7000 quantitative ultrasound BMD detector from Sunlight Company in Israel made BMD ultrasound examination in the left or right tibia of children. The data of the results of BMD were analyzed by EXECL2003 and SPSS13.0 software. Results 335 cases of 42-day-old infants had normal BMD of 45.4% (152/335) and low of 54.6% (183/335). The mothers with BMD of more than three months’ Rates were higher than those of infants under three months of calcium supplementation and vitamin D supplementation during pregnancy (P <0.05). The low BMD of breastfeeding infants was significantly lower than that of artificial feeding group and mixed feeding group (all P <0.05), and the low BMD of Uygur infants was significantly lower than that of Han infants (P <0.05). The infant’s sex, premature birth and birth season , Maternal age and other factors and infant BMD test results no significant correlation (P all> 0.05). CONCLUSIONS: During the third trimester of pregnancy, calcium supplementation and vitamin D have a positive effect on the maintenance of normal BMD in infants. Breastfeeding is the best way to keep your baby’s BMD normal.