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目的观察2型糖尿病患者血清抵抗素水平的变化,探讨血清抵抗素在2型糖尿病中的临床意义。方法选择2型糖尿病患者100例为T2DM组、正常健康人150例为对照组,测定所有研究对象的空腹血清抵抗素水平,并分析其与其它生化代谢指标的关系。结果2型糖尿病患者血清抵抗素水平显著高于健康人群(P<0.05)。2型糖尿病组血清抵抗素水平和空腹血糖(FBG)、空腹胰岛素(FIN)、胰岛素抵抗指数(IRI)呈显著正相关。多元逐步回归分析显示空腹血糖和空腹胰岛素是影响血清抵抗素水平的独立相关因素。对血清抵抗素水平进行ROC分析发现,血清抵抗素水平对2型糖尿病的诊断价值比较大。结论血清抵抗素水平与2型糖尿病有关,可能是2型糖尿病的危险因子。空腹血糖、空腹胰岛素是影响血清抵抗素水平的独立相关因素。血清抵抗素可作为诊断2型糖尿病较好指标。
Objective To observe the changes of serum resistin in type 2 diabetic patients and explore the clinical significance of serum resistin in type 2 diabetes mellitus. Methods 100 T2DM patients with type 2 diabetes mellitus and 150 healthy controls were selected as control group. Fasting serum resistin levels were measured in all subjects and their relationship with other biochemical metabolic parameters was analyzed. Results Serum resistin level was significantly higher in patients with type 2 diabetes than in healthy people (P <0.05). The level of serum resistin in type 2 diabetic patients was positively correlated with fasting blood glucose (FBG), fasting insulin (FIN) and insulin resistance index (IRI). Multivariate stepwise regression analysis showed that fasting blood glucose and fasting insulin were independent correlates of serum resistin levels. ROC analysis of serum resistin levels found that serum resistin levels in the diagnosis of type 2 diabetes is relatively large. Conclusion Serum resistin level is associated with type 2 diabetes and may be a risk factor for type 2 diabetes. Fasting blood glucose and fasting insulin are independent related factors that affect the level of serum resistin. Serum resistin can be used as a good indicator to diagnose type 2 diabetes.