Genes and regulatory networks involved in persistence of Mycobacterium tuberculosis

• 作 者: WANG XiaoZhen WANG HongHai XIE
• 机 构: InstituteofModernBiopharmaceuticals,StateKeyLaboratoryofGeneticEngineering
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2011年4期
• 关键词: 结核分枝杆菌 基因调控网络 多基因 免疫反应 休眠状态 分子机制 结核病 肺结核 Mycobacterium tuberculosis persistent
• 基金项目: This work was supported by the National Key Infectious Disease Project （Grant Nos. 2008ZX10003-006 and 2008ZX10003-001）, the Excellent PhD Thesis Fellowship of Southwest University （Grant Nos. kb20090

The causative agent of tuberculosis,Mycobacterium tuberculosis,is one of the most successful of human pathogens.It can evade the host immune response and establish a persistent infection or enter a dormant state within the host which can be reactivated if