【摘 要】
：
The protective antigen(PA)mediated internalization of the anthrax complexes is critical in the development of anthrax,which depends on specific membrane recepto
【机 构】
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State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy
【出 处】
：
Science China(Life Sciences)
论文部分内容阅读
The protective antigen(PA)mediated internalization of the anthrax complexes is critical in the development of anthrax,which depends on specific membrane receptors,namely ANTXR1(also known as TEM8)and ANTXR2(also known as CMG2)[1].In a screen for host proteins required for anthrax toxin action,low-density lipoprotein receptor-related protein 6(LRP6)was found important for efficient toxin entry in human M2182 prostate carcinoma cells[2],which interacts with both ANTXR1 and ANTXR2.However,the role of LRP6 in anthrax toxicity remains controversial as both in mice and in human HeLa cells,knockout or knockdown of LRP6 has no clear effect on their sensitivity to anthrax toxins[3].
The protective antigen (PA) mediated internalization of the anthrax complexes is critical in the development of anthrax, which depends on specific membrane receptors, namely ANTXR1 (also known as TEM8) and ANTXR2 (also known as CMG2) [1] .In a screen for host proteins required for anthrax toxin action, low-density lipoprotein receptor-related protein 6 (LRP6) was found important for efficient toxin entry in human M2182 prostate carcinoma cells [2], which interacts with both ANTXR1 and ANTXR2.However, the role of LRP6 in anthrax toxicity remains controversial as both in mice and in human HeLa cells, knockout or knockdown of LRP6 has no clear effect on their sensitivity to anthrax toxins [3].
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