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人类冠状动脉粥样硬化主要发生在较大冠状动脉近端6～8厘米处,常呈现为由各种脂质(包括胆固醇和胆固醇酯)、细胞以及由细胞合成之纤维蛋白所组成的血管内膜斑块。成熟斑块其占据空间的二个主要成份是纤维盖和坏死的粥样核心,这些成份合在一起可致使管腔发生重度狭窄。形成人类斑块(包括纤维盖)的主要细胞是平滑肌细胞,后者推测是从血管中层移行来的,并伴有血管内膜中这些细胞的过度增殖(有丝分裂)。脂质-胆固醇混合物似乎主
Human coronary atherosclerosis occurs predominantly 6-8 cm proximal to the larger coronary arteries and often appears as an intravascular region composed of various lipids (including cholesterol and cholesterol esters), cells, and fibrin synthesized by cells Membrane plaque. The two main components of mature plaques occupying the space are the fibrous cap and the necrotic atherosclerosis, which, taken together, can result in severe stenosis of the lumen. The primary cells that form human plaques, including the fibrous cap, are smooth muscle cells, which are presumed to migrate from the middle of the blood vessel, accompanied by hyperproliferation (mitosis) of these cells in the intima. Lipid-cholesterol mixture seems to be the main