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目的筛检燃煤砷致人体肝损伤的早期监测指标。方法应用生化及放射免疫法检测燃煤型砷中毒患者血清胆汁酸 (SBA)、γ 谷氨酰转移酶 (γ GT)、血管内皮素 (ET)、谷丙转氨酸 (ALT)等四项生化指标。结果各中毒组SBA和中、重度中毒组γ GT、ET水平均显著高于对照组 ,差异有显著性 ,而ALT水平各组均无差别。结论SBA水平能在砷中毒早期反映肝损伤情况 ,γ GT、ET水平则在病情发展至中、晚期显示异常 ;SBA、γ GT、ET三项指标联合检测在砷致肝损伤的筛检及动态观察其病情发展中有重要价值。
Objective To screen early indicators of liver injury induced by burning coal arsenic. Methods The biochemical and radioimmunoassay methods were used to detect the serum bile acid (SBA), γ-GT, ET and ALT in patients with coal-burning arsenism. Biochemical Indicators. Results The concentrations of γ-GT and ET in SBA and moderate and severe poisoning groups were significantly higher than those in control group, but there was no significant difference in each group. Conclusions The level of SBA can reflect the liver injury in the early stage of arsenic poisoning. The levels of γ-GT and ET are abnormal in the progression of the disease to the middle and late stage. The combined detection of SBA, γ-GT and ET in the detection of arsenic-induced liver injury and its dynamic Observe the development of their disease has important value.