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本文报道在日本仙台东北大学医院临床研究大楼动物实验室工作人员中的两次朝鲜出血热(KHF)爆发。第一次发生于1975年3～5月,有3名医生发病;第二次发生于1977年6月～1978年6月,有11名医生(包括1名兽医)发病,其中8名发病于12月～2月。临床症状及化验结果与一般KHF相同,但突出的症状有腹泻(10/13例)、肝肿大(9/10例)及脾肿大(5/9例)。此外尚有高热(39～40℃)、极度不适、短暂的肾脏损害、血
This article reports two outbreaks of North Korean hemorrhagic fever (KHF) in the animal laboratory staff in the Clinical Research Building, Tohoku University Hospital, Sendai, Japan. The first occurred in March-May 1975, with the onset of three doctors. The second occurred in June 1977-June 1978, and 11 doctors (including one veterinarian) developed. Eight of them December ~ February. Clinical symptoms and laboratory findings were the same as for general KHF, but prominent symptoms were diarrhea (10/13), hepatomegaly (9/10) and splenomegaly (5/9). In addition there are high fever (39 ~ 40 ℃), extremely uncomfortable, transient renal damage, blood