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某女,35岁,身体健康.接受本校生产的人白细胞α-干扰素的安全性试验,每周肌注2～3次,每次5ml(1万U/ml).连续注射2个月后,出现闭经.又连续注射3个多月,一直未来月经.妊娠试验阴性,注射大剂量黄体酮3天后,发生撤退性出血.自此,停用干扰素,月经恢复正常.该例无慢性病史,月经一直正常,从未发生过闭经,正常分娩2次,无妇科疾患.采取上环节育措施,从未服用避孕药.故怀疑闭经可能与注射干扰素有关,且该
A female, 35 years old, good health.Absence of leukemia interferon safety test in our school, intramuscular injection of 2 to 3 times a week, each 5ml (10,000 U / ml) .After 2 consecutive months of injection , Amenorrhea.And continuous injection of more than three months, has been the future of menstruation.Negative pregnancy test, after injection of large doses of progesterone 3 days, the occurrence of withdrawal bleeding.From this, stop interferon, menstruation returned to normal.This case without chronic disease history , Menstruation has been normal, never had amenorrhea, the normal delivery 2 times, no gynecological disorders .Take the ring birth control measures, never taking birth control pills .It is suspected that amenorrhea may be related to the injection of interferon, and the