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目的:对清肺消痰解痉汤联合沙丁胺醇气雾剂对支气管哮喘的临床疗效进行探讨。方法:选取达州市中心医院2010年2月—2014年5月收治的128例支气管哮喘(寒哮)患者作为研究对象,随机分为观察组和对照组,每组各64例。两组患者均给予常规沙丁胺醇气雾剂,100μg/次,每日4次,观察组患者则在此基础上加以口服中药清肺消痰解痉汤,每日1剂,分早晚2次温服。两组患者分别于治疗前和治疗12周后对其肺通气功能,最大呼气峰流速(peak expiratory flow,PEF),哮喘控制测试评分(asthma control test score,ACT)及中医证候积分进行检测和评价,并结合上述结果对其临床疗效进行比较分析。结果:治疗后两组患者各项观察指标均较治疗前有明显改善,其中观察组患者相比对照组患者第一秒用力呼气容积(forced expiratory volume in one second,FEV1),PEF及ACT评分明显升高,中医证候积分明显降低,且观察组临床控制率较对照组明显提高,而无效率则明显降低,差异均具有统计学意义。结论:清肺消痰解痉汤联合沙丁胺醇可有效改善支气管哮喘发作期(寒哮)患者的肺通气功能,缓解其临床症状,提高临床控制率,相比单一的沙丁胺醇气雾剂治疗疗效更佳。
Objective: To investigate the clinical effects of Qingfei Xiaotan Jieji Decoction combined with salbutamol aerosol on bronchial asthma. Methods: A total of 128 patients with bronchial asthma (cold asthma) treated in Dazhou Central Hospital from February 2010 to May 2014 were randomly divided into observation group and control group, with 64 cases in each group. Two groups of patients were given conventional salbutamol aerosol, 100μg / time, 4 times a day, the observation group patients were on the basis of oral Chinese medicine Qingfei Phlegm spasm soup one day a day, minutes and nights twice warm service . Two groups of patients were tested for pulmonary ventilation function, peak expiratory flow (PEF), asthma control test score (ACT) and TCM syndrome score before and 12 weeks after treatment respectively And evaluation, combined with the above results to compare the clinical efficacy. Results: After treatment, the observation indexes of both groups were significantly improved compared with that before treatment, in which the forced expiratory volume in one second (FEV1), PEF and ACT scores of patients in the observation group compared with the control group Significantly increased, TCM syndrome score was significantly lower, and the observation group clinical control rate was significantly higher than the control group, while the inefficiency was significantly lower, the differences were statistically significant. Conclusion: Qingfei Xiaotan Jiezuo Decoction combined with albuterol can effectively improve pulmonary ventilation, relieve clinical symptoms and improve clinical control rate in patients with bronchial asthma exacerbation (cold), which is more effective than single salbutamol aerosol .