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目的探讨强直性脊柱炎(AS)活动期与非活动期白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C-反应蛋白(CRP)之间的关系。方法检测28例活动期、40例非活动期AS患者以及25例健康人血清中TNF-α、IL-6、CRP的含量。结果活动期AS患者血清中的TNF-α、IL-6、CRP的含量明显高于非活动期患者,有统计学意义(P<0.001),且活动期AS患者的年龄较非活动期患者小、病程也较非活动期短。非活动期患者血清中的TNF-α、IL-6的含量较正常对照组高,且有统计学意义(P<0.05)。结论 AS患者血清巾的TNF-α、IL-6、CRP的浓度与疾病活动程度有关,即使在非活动期AS患者体内仍存在一系列免疫活动,故应在早期积极控制病情的进展,同时也不能忽视非活动期。
Objective To investigate the relationship between interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) in the active and inactive phases of ankylosing spondylitis (AS) Methods Serum levels of TNF-α, IL-6 and CRP were measured in 28 active cases, 40 inactive AS patients and 25 healthy volunteers. Results The serum levels of TNF-α, IL-6 and CRP in patients with active AS were significantly higher than those in inactive patients (P <0.001), and the age of active AS patients was smaller than that of inactive patients , The duration is shorter than the inactive period. Serum levels of TNF-α and IL-6 in inactive patients were significantly higher than those in normal controls (P <0.05). CONCLUSIONS: Serum levels of TNF-α, IL-6 and CRP in patients with AS are related to the degree of disease activity. Even in patients with inactive AS, there is still a series of immunological activities in patients with AS. Therefore, the progress of the disease should be actively controlled in the early stage, Can not ignore the inactive period.