丙型肝炎病毒在供、受血者间传播的调查

• 作 者: 李方和 黄元成 唐振亚 申正义 汪由坤 喻植群 杨东亮 郝连杰
• 机 构: 同济医科大学附属同济医院临床免疫学研究室!武汉,430030,同济医科大学附属同济医院临床免疫学研究室!武汉,430030,同济医科大学附属同济医院临床免疫学研究室!武汉,430030,同济医科大学附
• 出 处: 同济医科大学学报
• 发表日期: 1997年03期
• 关键词: 受血者 肝炎病毒 丙型肝炎病毒 输血 病毒抗体 献血员 检测阳性率 清抗 肝炎病毒抗体 肝炎

采用市售第二代抗HCVELISA试剂对一组供、受血者血清抗HCV进行了抽查。结果表明，未经地方血站抗HCV筛选的献血员血清抗HCV阳性率为18．57％，经筛选后为1．03％～5．24％，正常人群为1．98％，同期受血者为7．59％，抗HCV阳性与阴性献血者HCVRNA检测阳性率分别为56．8％与20．0％。在9例接受抗HCV阳性血液的受血者中，1例患者受血前后抗HCV均为阳性，5例抗HCV及6例HCVRNA阳转，6例血清HCV感染标志阳转者中4例ALT明显较正常为高，其中3例因临床症状较重而再次住院治疗。研究还发现3例输血感染者所接受的血液中抗HCV呈低表达状态（采用ELISA检测，OD值0．22～0．39），并对此进行了讨论。

Using a commercially available second-generation anti-HCV ELISA reagent for a set of donor and recipient blood serum anti-HCV were spot checks. The results showed that the positive rate of anti-HCV seroprevalence was 18.57% in blood donors without local anti-HCV screening, 1.03% -5.24% after screening, 1.98% in normal population, Were 7.59%. The positive rates of HCV RNA in anti-HCV positive and negative blood donors were 56.8% and 20.0%, respectively. Among 9 blood recipients who received anti-HCV positive blood, 1 patient was positive for anti-HCV before and after anti-HCV, 5 anti-HCV and 6 HCV RNA were positive, and 6 of 6 HCV seroprevalence markers were positive for ALT Obviously higher than normal, of which 3 were hospitalized again due to clinical symptoms. The study also found that 3 of the blood transfusions received blood anti-HCV was low expression (using ELISA test, OD value 0.22 ~ 0.39), and this was discussed.