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血红蛋白是分子生物学、分子遗传学研究的一种理想材料,正是通过对血红蛋白的深入研究,特别是体细胞融合、DNA分子杂交和限制性内切酶技术的应用,进一步揭示了人类基因的结构、蛋白质生物合成的遗传控制等分子遗传学重要问题。本文就血红蛋白分子遗传学近几年来的一些研究进展作简要的评述。血红蛋白的发育演变要认识正常人血红蛋白合成的遗传控制,首先需要了解人体内正常血红蛋白的组成和它在发育期间的演变。在人体发育过程的不同时期,血红蛋白的组成各不相同,在胚胎期间,即妊娠的前8周内,主要有三种胚胎血红蛋白:Hb Gower 1(ξ_2ε_2),HbGower 2(α_2ε_2)和Hb Portland(ξ_2γ_2),
Hemoglobin is an ideal material for molecular biology and molecular genetics. It is through the further study of hemoglobin, especially the application of somatic cell fusion, DNA molecular hybridization and restriction enzyme technology, further revealed that human genes Structure, genetic control of protein biosynthesis and other important molecular genetics issues. This article briefly reviews the progress of some studies on hemoglobin molecular genetics in recent years. Hemoglobin Development To understand the genetic control of normal hemoglobin synthesis, you first need to understand the body’s normal hemoglobin composition and its evolution during development. There are three main types of hemoglobin during the first 8 weeks of pregnancy: Hb Gower 1 (ξ_2ε_2), HbGower 2 (α_2ε_2) and Hb Portland (ξ_2γ_2 ),