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目的探讨肝组织G1～G2慢性乙型肝炎患者HBV DNA、HBeAg含量、ALT以及超声检查的变化。方法对肝组织学表现为G1～G2的126例慢性乙型肝炎患者的临床资料进行了分析。结果G1患者的纤维化分期主要在S0～S1期,G2患者则主要集中在S2～S3两期;G1患者脾脏厚度较G2小(P=0.012),但G1与G2患者的年龄、ALT、AST、HBV DNA、门静脉内径和脾静脉内径无统计学差异;随着纤维化程度的增加,血清HBeAg阴性患者的比例有增加的趋势(P<0.05)。结论脾厚是早期反映肝脏炎症坏死和肝纤维化进展的敏感指标。
Objective To investigate the changes of HBV DNA, HBeAg, ALT and ultrasound in patients with chronic hepatitis B from G1 to G2. Methods The clinical data of 126 patients with chronic hepatitis B who had histological manifestations of G1 ~ G2 were analyzed. Results The G1 stage was mainly in the stage of S0 ~ S1. The G2 stage was mainly in the stage S2 ~ S3. The G1 stage was smaller than the G2 in G2 stage (P = 0.012). However, the age, ALT, AST , HBV DNA, the diameter of portal vein and the diameter of splenic vein had no statistical difference. With the increase of fibrosis, the proportion of serum HBeAg-negative patients increased (P <0.05). Conclusions Splenomegaly is a sensitive indicator of the early stage of liver inflammation, necrosis and liver fibrosis.