论文部分内容阅读
目的:研究急性胰腺炎(AP)病人的临床流行病学特征。方法:收集1996~2012年本院收治的4 800例AP病人,分析性别、年龄、病因学及预后等临床特征及变化趋势。结果 :男2 832例(59.0%),女1 968例(41.0%),平均年龄分别为(51.5±16.6)岁、(54.1±17.4)岁,发病年龄随时间无明显变化。胆源性(69.0%)、高脂血症性(7.4%)及酒精性(2.3%)是前三位原因。胆源性AP比例稳定(1996~2000年61.9%,2001~2006年70.7%,2007~2012年70.8%);高脂血症性AP比例明显上升AP(1996~2000年2.6%,2001~2006年6.6%,2007~2012年14.1%);酒精性AP比例轻度上升(1996~2000年1.4%,2001~2006年1.7%,2007~2012年3.3%)。各病因之间死亡率无统计学差异(P=0.18)。总体死亡率为4.7%,呈现下降趋势(1996~2000年5.3%,2001~2006年4.8%,2007~2012年4.2%)。平均住院时间为(25.0±34.5)d,住院费用为(75 750±18 000)元(2012可比价格计算),两者均呈下降趋势。结论 :51~60岁为AP最多发年龄段,胆源性是最主要病因,高脂血症性AP增加最显著。
Objective: To study the clinical epidemiological characteristics of patients with acute pancreatitis (AP). Methods: A total of 4800 AP patients admitted to our hospital from 1996 to 2012 were collected. The clinical features and trends of gender, age, etiology and prognosis were analyzed. Results: There were 2 832 males (59.0%) and 1 968 females (41.0%) with average age of (51.5 ± 16.6) years and (54.1 ± 17.4) years, respectively, with no significant difference in age of onset. Biliary (69.0%), hyperlipidemia (7.4%) and alcohol (2.3%) are the top three reasons. The proportion of biliary AP was stable (from 61.9% in 1996 ~ 2000, 70.7% in 2001 ~ 2006 and 70.8% in 2007 ~ 2012). The proportion of AP with hyperlipidemia increased significantly (AP, 2.6% from 1996 to 2000, from 2001 to 2006 Year 6.6%, and 2007 ~ 2012 14.1%). The proportion of alcoholic AP increased slightly (from 1.4% in 1996 ~ 2000, 1.7% in 2001 ~ 2006, and 3.3% in 2007 ~ 2012). There was no significant difference between the etiologies (P = 0.18). The overall mortality rate was 4.7%, showing a downward trend (5.3% from 1996 to 2000, 4.8% from 2001 to 2006 and 4.2% from 2007 to 2012). The average hospital stay was (25.0 ± 34.5) days and hospitalization costs were (75 750 ± 18 000) yuan (2012 comparable prices), both of which showed a downward trend. CONCLUSIONS: The most frequent age of AP occurred in 51-60 years old. Gallbladder was the most important cause, and the most significant increase was in hyperlipidemic AP.