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一、老年人的药物动力学特点与抗生素的使用:①老年人因胃肠道粘膜上皮细胞数量减少,胃肠活动和括约肌活性减弱,胃肠血流最减少,使口服抗生素的吸收速度减慢,吸收量减少,故一般剂量较难达到有效血浓度。②老年人代谢组织量减少(特别是肝脏)易使抗生素的代谢速度下降(尤其是主要在肝脏代谢的红霉素、氯霉素、四环素等),半衰期延长,故易在体内蓄积而增加对肝、肾等脏器
First, the pharmacokinetics of the elderly and the use of antibiotics: ① the elderly due to decreased number of gastrointestinal mucosal epithelial cells, decreased gastrointestinal motility and sphincter activity, gastrointestinal blood flow the most reduced, the absorption of oral antibiotics slowed down , Reduce the amount of absorption, it is generally difficult to achieve effective dose of blood concentration. (2) the metabolism of the elderly to reduce the amount of tissue (especially the liver) is easy to make the antibiotic metabolism rate (especially in the liver metabolism of erythromycin, chloramphenicol, tetracycline, etc.), half-life prolonged, it is easy to accumulate in the body and increase Liver, kidney and other organs