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目的：评估熊去氧胆酸（ＵＤＣＡ）治疗妊娠期肝内胆汁淤积症（ＩＣＰ）的效果。方法：选择６０例ＩＣＰ病人，分成两组，观察组（ｎ＝３０）采用ＵＤＣＡ１００ｍｇ每日３次，对照组（ｎ＝３０）采用黄疸茵陈冲剂２０ｇ每日３次，观察治疗效果。结果：观察组瘙痒评分治疗１周后明显下降，血ＡＬＴ、ＴＢＡ、ＣＨＯ、ＴＧ也明显下降（Ｐ＜００５），而对照组下降缓慢，同时还发现观察组产时缺氧发生率低，孕周较长，新生儿体重较重，剖宫产率较低，Ｐ＜００５。结论：ＵＤＣＡ是治疗ＩＣＰ安全有效的药物。
Objective: To evaluate the effect of ursodeoxycholic acid (UDCA) on intrahepatic cholestasis of pregnancy (ICP). Methods: Sixty patients with ICP were divided into two groups. The observation group (n = 30) received UDCA100mg three times a day, while the control group (n = 30) used jaundice Yinchen granules 20g three times daily to observe the therapeutic effect. Results: The score of pruritus in observation group decreased significantly after 1 week of treatment, and the levels of ALT, TBA, CHO and TG were also decreased (P <005), while the control group decreased slowly. The incidence of hypoxia in observation group was also lower , Gestational age longer, heavier newborns, cesarean section rate was lower, P <0 05. Conclusion: UDCA is a safe and effective drug for the treatment of ICP.