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目的:用Meta分析评价经腹腔入路腹腔镜前列腺癌根治术(TLRP)与经腹膜外入路腹腔镜前列腺癌根治术(ELRP)治疗局限性前列腺癌的疗效和安全性。方法:通过计算机检索Medline、Cochrane临床对照试验中心数据库、中国学术期刊全文数据库、万方数据库和中国生物医学文献数据库,按纳入和排除标准,两位研究员独立进行文献筛查、质量评价和数据提取,交叉核对,并用Stata12.0软件进行Meta分析评价手术时间、术中出血量、术后尿管留置天数、肠功能恢复时间、术后住院天数等相关指标。结果:共纳入9篇文献,共942例患者,其中行TLRP患者492例,行ELRP患者450例。Meta分析结果显示:TLRP与ELRP两者在手术时间[SMD=0.60,95%CI(-0.06,1.26)]、术中出血量[SMD=0.01,95%CI(-0.35,0.36)]、术后留置尿管时间[SMD=0.10,95%CI(-0.21,0.40)]、术后住院天数[SMD=0.45,95%CI(-0.01,0.91)]方面无统计学差异,在肠功能恢复时间[SMD=1.18,95%CI(0.26,2.10)]有显著性差异。结论:TLRP和ELRP在治疗局限性前列腺癌在手术时间、术中出血量、留置尿管时间、术后住院天数方面无统计学差异,在肠功能恢复时间上,ELRP比TLRP更具有优势。
OBJECTIVE: To evaluate the efficacy and safety of meta-analysis of percutaneous transluminal laparoscopic radical prostatectomy (TLRP) and extraperitoneal laparoscopic radical prostatectomy (ELRP) in the treatment of localized prostate cancer. METHODS: Medline, Cochrane Central Register of Controlled Trials Database, Chinese Academic Journal Full-text Database, Wanfang Database and China Biomedical Literature Database were searched by computer. According to inclusion and exclusion criteria, the two researchers independently conducted literature screening, quality evaluation and data extraction , And cross-checked. Stata12.0 software Meta-analysis to evaluate the operation time, intraoperative blood loss, postoperative catheter indwelling days, intestinal function recovery time, postoperative hospital days and other related indicators. Results: A total of 9 articles were included in 942 patients, including 492 TLRP patients and 450 ELRP patients. The results of Meta analysis showed that there was significant difference between TLRP and ELRP at operation time [SMD = 0.60,95% CI (-0.06,1.26)], intraoperative blood loss [SMD = 0.01,95% CI (-0.35,0.36) There was no significant difference in postoperative catheterization time [SMD = 0.10, 95% CI (-0.21, 0.40)] and postoperative hospital stay [SMD = 0.45,95% CI (-0.01,0.91] There was a significant difference in time [SMD = 1.18, 95% CI (0.26, 2.10)]. Conclusion: There is no significant difference between TLRP and ELRP in the treatment of localized prostate cancer at operation time, intraoperative blood loss, indwelling catheter time and postoperative hospital stay. ELRP has more advantages than TLRP in the recovery of intestinal function.