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目的 探索支气管哮喘病人嗜酸性粒细胞凋亡情况。方法 对 3 0例支气管哮喘病人分别于急性发作期、缓解期和 3 0例健康人经纤维支气管镜取支气管肺泡灌洗液用免疫细胞组化方法进行嗜酸性粒细胞凋亡的研究。结果 支气管哮喘病人急性发作期 ,治疗后的缓解期和健康人组EOS凋亡百分比分别是 (3 .50± 1.59) % ,(5.53± 2 .2 2 ) %和 (6.90± 3 .2 7) %。三组间差异显著 (P均 <0 .0 0 1)。结论 支气管哮喘病人存在着EOS凋亡异常 ,经激素治疗后可改善EOS凋亡。EOS凋亡是支气管哮喘发病机理中的主要环节之一。
Objective To explore the eosinophil apoptosis in patients with bronchial asthma. Methods Thirty patients with bronchial asthma were randomly divided into three groups: acute exacerbation, remission and 30 bronchial alveolar lavage with bronchial bronchoalveolar lavage (BALF). Eosinophil apoptosis was evaluated by immunohistochemistry. Results The percentages of apoptosis of EOS in patients with bronchial asthma at acute attack, remission and healthy controls were (3.50 ± 1.59)%, (5.53 ± 2.2.2%) and (6.90 ± 3.27), respectively %. The difference between the three groups was significant (P <0.01). Conclusion There is abnormal EOS apoptosis in patients with bronchial asthma, which can improve the apoptosis of EOS after steroid treatment. EOS apoptosis is one of the main links in the pathogenesis of bronchial asthma.