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作者报道1例霍奇金病(HD)患者化疗后获完全缓解(CR)已4年,其血液学指标虽然一直正常,但生物学和遗传学检测却揭示存在骨髓增生异常综合征(MDS)的特征性异常。 患者:女性26岁。1986年因患结节硬化型HD(Ⅳ期A)接受6个疗程的MOPP方案(氮芥、长春新硷、甲基牙肼和强的松龙)治疗后获CR。1990年发现右颈淋巴结肿大,活检证实系HD复发,经局部放疗治愈。HD局部复发时和7个月后两次骨髓染色体检查分别发现5/20和5/60个分裂相有7号染色体长臂的部分缺失[del(7)(q31.6 q36]。治疗后1和4年两度采集外周血标本进行聚合酶链反应以
The authors report that one patient with Hodgkin’s disease (HD) had a complete remission (CR) for 4 years after chemotherapy and that although hematologic parameters were consistently normal, biological and genetic tests revealed the presence of myelodysplastic syndrome (MDS) The characteristic abnormalities. Patient: Female 26 years old. CR was obtained after 6 courses of MOPP regimen (mechlorethamine, vincristine, methyl hydrazine, and prednisolone) receiving nodular cirrhosis type HD (stage IV A) in 1986. Right neck lymph node enlargement was found in 1990, biopsy confirmed the Department of HD recurrence, cured by local radiotherapy. Two bone marrow chromosomal examinations at the time of local recurrence of HD and after 7 months revealed a partial deletion of the long arm of chromosome 7 in 5/20 and 5/60 schizophrenia [del (7) (q31.6 q36)]. After treatment 1 And 4 years to collect peripheral blood samples for polymerase chain reaction