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目的:探讨矮小症肾精亏虚型动物模型的研制。方法:对孕鼠采用烟熏法造成宫内发育迟缓模拟矮小,选择该模型雄鼠并在此基础上再予房劳和惊恐造成肾精亏虚,造成矮小症肾精亏虚雄性大鼠病证结合模型。结果:研究表明,矮小症肾精亏虚雄性大鼠病证结合模型雄鼠的外观表现、睾丸脏器指数、体重和股骨长测量、血清睾丸酮(T)、雌二醇(E2)、股骨和下丘脑形态学改变均有异于正常对照组。结论:宫内发育迟缓结合房劳和惊恐可较好地模拟矮小症肾精亏虚模型。
Objective: To investigate the development of deficiency syndrome animal model of shortness of kidney deficiency. Methods: The intrauterine growth retardation model of dwarfism caused by shortness of breath syndrome was used to simulate dwarfism. Card combination model. Results: The results showed that appearances, testicular organ index, body weight and femur length measurement, serum testosterone (T), estradiol (E2), femur and femur Hypothalamus morphological changes are different from the normal control group. Conclusions: Intrauterine growth retardation combined with room service and panic can better simulate deficiency of kidney deficiency model in short stature.