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Aim:To investigate the effects of depside salts from Salvia miltiorrhiza on myo-cardial microperfusion and systemic hemodynamics in open-chest anaesthetizedSprague-Dawley rats.Methods:Myocardial microperfusion was measured bylaser Doppler flowmetry with a needle probe;cardiac output (CO) was determinedusing ultrasonic Doppler flowmetry.Other hemodynamic parameters,includingfemoral artery blood pressure,cardiac inotropy,and systemic vascular resistance(SVR) were simultaneously recorded by the PowerLab system.Results:Intrave-nous administration of S miltiorrhiza depside salts resulted in a significant imme-diate increase in CO and cardiac inotropy,but a fall in SVR.S miltiorrhiza depsidesalts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P<0.01vs baseline) and 20.1%±3.5% (P<0.01),respectively.Myocardial microperfusionmaximally increased by 6.3%±2.9% (P<0.01) and 9.6%±4.0% (P<0.01) for 30 mg/kgand 60 mg/kg S miltiorrhiza depside salts,respectively.Conclusion:Theseresults indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion,as well as CO.
Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myo-cardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats. Methods: Myocardial microperfusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using Ultrasound Doppler flowmetry .Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were recorded simultaneously by the PowerLab system. Results: Intrave nous administration of S miltiorrhiza depside salts resulted in a significant imme-diate increase in CO and cardiac inotropy, but a fall in SVR. Miltiorrhiza depsides (30 mg / kg and 60 mg / kg) promoted cardiac index (CI) % (P <0.01), respectively. Myocardial microperfusionmaximally increased by 6.3% ± 2.9% (P <0.01) and 9.6% ± 4.0% for 30 mg / kg and 60 mg / kg S miltiorrhiza depside salts, respectively. Conclusion: These results indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion, as well as CO.