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外源性化学毒物侵入机体后,有些是以其原形发挥毒性作用,大多数则在酶的作用下,改变了分子结构,导致增强或减弱原有的毒性。毒物在体内发生的一系列生物转化过程即毒物的代谢过程,通常分为两期反应:第一期反应是在酶的作用下改变了毒物分子的功能基团;第二期反应是毒物或其代谢物同内源性小分子化合物结合。毒物的具体代谢途径如下: 第一期反应氧化反应混合功能氧化酶脱氢反应氧化酶(单胺氧化酶) 还原反应偶氮还原硝基还原羰基还原水解反应
Exogenous chemical poisons invade the body, some of them play a role in its virulence, most of the role of the enzyme, changing the molecular structure, leading to increase or decrease the original toxicity. A series of biotransformation processes of poisons in the body, namely the metabolic process of poisons, are usually divided into two phases: the first phase changes the functional groups of toxic molecules under the action of enzymes; the second phase reactions are poisons or their Metabolites bind to endogenous small molecule compounds. The specific metabolic pathways of toxicants are as follows: The first phase of the reaction Oxidation reaction Mixed function Oxidase dehydrogenase Oxidase (monoamine oxidase) Reduction reaction Azo reduction Nitro reduction Carbonyl reduction Hydrolysis