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目的：探讨狼疮肾炎（ＬＮ）患者血清白细胞介素－１０（ｓＩＬ—１０）水平改变与狼疮疾病活动的关系及意义。方法：应用酶联免疫法（ＥＬＩＳＴ）测定３８例ＬＮ患者和２２例健康志愿者ｓＩＬ－１０水平，同时应用狼疮疾病活动指数（ＳＬＥＤＡＩ）对 ＬＮ患者进行疾病活动评分，并对两者进行相关分析。结果： ＬＮ患者 ｓＩＬ－ １０水平明显较正常健康对照组高（１９．７±７．２ ｐｇ／ｍｌ ｖｓ １２．０±２，９ ｐｇ／ｍｌ，Ｐ＜０．０５），对ＳＬＥＤＡＩ与ｓＩＬ－１０水平进行Ｐｅａｒｓｏｎ直线相关分析，其相关系数ｒ＝０．１０５，Ｐ＝０．６０９（Ｐ＞０．０５），提示ＬＮ患者ＳＩＬ－１０水平与疾病活动指数无相关性。结论：ＬＮ患者血清白细胞介素－１０异常升高可能是一种内源性的异常而与狼疮疾病活动无明显相关性。
Objective: To investigate the relationship between serum interleukin-10 (sIL-10) level and lupus disease activity in patients with lupus nephritis (LN). Methods: Serum levels of sIL-10 were measured in 38 patients with LN and 22 healthy volunteers by enzyme-linked immunosorbent assay (ELISA), and the disease activity score of patients with LN was evaluated by the lupus disease activity index (SLEDAI) . Results: The level of sIL-10 in LN patients was significantly higher than that in healthy controls (19.7 ± 7.2 pg / ml vs 12.0 ± 2, 9 pg / ml, P <0.05) 10 level by Pearson linear correlation analysis, the correlation coefficient r = 0.105, P = 0.609 (P> 0.05), suggesting that LN patients with SIL-10 levels and disease activity index no correlation. CONCLUSIONS: Elevated serum interleukin-10 in patients with LN may be an endogenous abnormality without significant correlation with lupus disease activity.