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[目的]观察茵栀黄注射液联合西药治疗自身免疫性肝炎疗效。[方法]使用随机平行对照方法,将30例门诊患者按抛硬币法简单随机分为两组。对照组15例强的松,20mg/次,2次/d。硫唑嘌呤,50mg/次,2次/d。治疗组15例茵栀黄注射液10m L+10%葡萄糖250m L,2次/d,静滴;西药治疗同对照组。连续治疗90d为1疗程。观测临床症状、层黏蛋白、IV胶原、透明质酸、Ⅲ型前胶原蛋白肽、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效8例,有效5例,无效2例,总有效率88.67%。对照组显效4例,有效4例,无效7例,总有效率53.33%。治疗组疗效优于对照组(P<0.05)。肝纤维指标两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]茵栀黄注射液联合西药治疗自身免疫性肝炎疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Yinzhihuang injection and western medicine on autoimmune hepatitis. [Method] Using random parallel control method, 30 outpatients were randomly divided into two groups according to the coin tossing method. Control group, 15 cases of prednisone, 20mg / time, 2 times / d. Azathioprine, 50mg / time, 2 times / d. In the treatment group, 15 cases of Yinzhihuang injection 10m L + 10% glucose 250ml, 2 times / d, intravenous infusion; Western medicine treatment with the control group. Continuous treatment of 90d for a course of treatment. Clinical symptoms, laminin, IV collagen, hyaluronic acid, procollagen type III peptide, adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Result] In the treatment group, 8 cases were markedly effective, 5 cases were effective, 2 cases were ineffective, and the total effective rate was 88.67%. In the control group, 4 cases were markedly effective, 4 cases were effective, 7 cases were ineffective, with a total effective rate of 53.33%. The treatment group was better than the control group (P <0.05). Liver fibrosis index improved in both groups (P <0.01), the treatment group improved better than the control group (P <0.01). [Conclusion] Yinzhihuang injection combined with Western medicine in the treatment of autoimmune hepatitis has satisfactory curative effect and no serious adverse reactions, which deserves promotion.