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本文以神经内分泌免疫调节网络学说及祖国医学的整体观为指导思想,研究观察了我国民间常用草药绞股蓝的活性成分——绞股蓝总皂甙(GPS)对大鼠脾脏淋巴细胞增殖功能的影响及其与下丘脑,脾脏去甲肾上腺素(NE)以及血浆皮质酮的相互关系,结果表明,大鼠ip GPS,10及20 mg·kg·d~(-1)共7d,其脾细胞对丝裂原Con A诱导的增殖反应明显增强,以10 mg·kg·d~(-1)剂量组更为显著,同时,以高效液相色谱电化学检测器测定单胺类神经递质的结果表明,下丘脑NE含量下降,脾脏NE亦明显降低,与脾细胞增殖反应呈负相关;此外,血浆皮质酮水平下降,结果提示,GPS对免疫反应的影响,与作用于神经内分泌免疫调节网络,进而发挥免疫增强作用具有密切关系。
In this paper, neuroendocrine immune regulation network theory and the concept of holism as the guiding ideology of the motherland, the study observed the active ingredient of our common folk medicine Gynostemma - Gypenosides (GSP) on rat spleen lymphocyte proliferation and its effect Hypothalamus, norepinephrine (NE) and plasma corticosterone in rats. The results showed that the rats were given ip GPS at 10 and 20 mg · kg · d -1 for 7 days, Con A induced a significant increase in proliferative response to 10 mg · kg · d -1 dose group was more significant at the same time, high performance liquid chromatography electrochemical detection of monoamine neurotransmitter results show that the next The content of NE in the thalamus decreased and the spleen NE also decreased significantly, which was negatively correlated with the splenocyte proliferation reaction. In addition, the plasma corticosterone level decreased, suggesting that the effect of GPS on the immune response and the neuroendocrine immune regulatory network, Enhancement is closely related.