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DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (DP 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.