无精少精不育症的染色体分析

• 作 者: 吴美衡 谭新诺
• 机 构: 淮阴市妇儿医院
• 出 处: 南京医科大学学报
• 发表日期: 1995年02期
• 关键词: 无精证 少精症 染色体异常 不育症 azoospermiaoligospermiaabnormality of chromosome

排除诸多其它原因引起的男性不育，就５０例无精子和少精子患者进行染色体分析，结果发现１８例染色体的数目与结构异常。其中２例经湖南医科大学国家医学遗传中心鉴别系世界首报核型。１８例中，性染色体异常１３例，又以４７，ＸＸＹ纯合型为最高，达１０例之多。常染色体异常者有５例，其中各种易位３例，缺失和标记染色体各１例。本文并讨论了无精子、少精子不育患者与染色体之间的关系。

Excluding many other causes of male infertility, chromosomal analysis of 50 cases of azoospermic and oligospermia patients found that 18 cases of chromosome number and structural abnormalities. Two of them were identified by the National Medical Genetics Center of Hunan Medical University as the world’s first karyotype. Eighteen cases, 13 cases of sex chromosome abnormalities, but also 47, XXY homozygous for the highest, up to 10 cases. There are 5 cases of autosomal abnormalities, including 3 cases of various translocations, 1 case of missing and labeled chromosomes. This article also discusses the relationship between azoospermia and oligospermic infertility and chromosomes.