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目的:观察纳洛酮联合还原型谷胱甘肽治疗急性酒精中毒的疗效。方法:选择急性酒精中毒64例,随机分为观察组和对照组各32例。对照组采用纳洛酮注射液静脉推注;观察组在对照组基础上,给予还原型谷胱甘肽注射剂1.2 g,加入到10%葡萄糖液100 ml静脉滴注。记录并比较两组神志及肢体运动恢复正常时间,并观察不良反应。结果:两组轻度酒精中毒患者神志及四肢运动恢复正常时间差异不显著(P>0.05);观察组中度、重度酒精中毒神智及肢体运动恢复正常时间显著或非常显著短于对照组(P<0.05,P<0.01)。两组均未发现不良反应。结论:纳洛酮联合还原型谷胱甘肽治疗中重度急性酒精中毒疗效较好,且较安全。
Objective: To observe the efficacy of naloxone combined with reduced glutathione in the treatment of acute alcoholism. Methods: 64 cases of acute alcoholism were randomly divided into observation group and control group, 32 cases each. The control group received intravenous injection of naloxone injection; the observation group was given 1.2 g of reduced glutathione injection on the basis of the control group, and added to 100 ml of 10% glucose solution by intravenous drip. Record and compare the two groups of consciousness and limb movement back to normal time, and observe the adverse reactions. Results: There was no significant difference between the two groups (P> 0.05) .Conclusion The moderate and severe alcoholism and limb movement recovery time in the observation group was significantly or very significantly shorter than that in the control group <0.05, P <0.01). No adverse reactions were found in both groups. Conclusion: Naloxone combined with reduced glutathione treatment of moderate and severe acute alcohol poisoning is better and safer.