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采用丙氨酸作为疏水聚合单体,谷氨酸作为亲水聚合单体,一步开环聚合反应,合成了具有两亲性的聚氨基酸无规共聚物.利用IR,1H-NMR等方法对所合成的聚合物进行了详细的表征,结果表明两种单体都能够按照投料比参加聚合反应生成无规共聚物.对比聚丙氨酸-聚羟丙谷氨酰胺嵌段共聚物,探讨了无规共聚物与嵌段共聚物在两亲性及结构性质上的差异和特点.研究表明,聚(L-丙氨酸-co-羟丙-L-谷氨酰胺)无规共聚物与嵌段共聚物一样,具有两亲性,在水溶液中也能够形成胶束,但胶束尺寸较嵌段共聚物要小,胶束形态也不像嵌段共聚物是规整的球形.实验发现,亲疏水单体的比例对胶束的形成有很大影响,P(A10-co-HPG40)所制得的胶束分散最为均匀.所形成的胶束以疏水的聚丙氨酸为内核,亲水的聚羟丙谷氨酰胺为外壳.
Using alanine as the hydrophobic polymerization monomer and glutamic acid as the hydrophilic polymerization monomer, one-step ring-opening polymerization was carried out to synthesize a random copolymer of amphiphilic polyamino acids. By means of IR, 1H-NMR and other methods, The synthesized polymer was characterized in detail and the results showed that both monomers could participate in the polymerization reaction according to the feed ratio to produce the random copolymer.Compared with the polyalanine polyhydroxypropyl glutamine block copolymer, Differences and characteristics of amphiphilic and structural properties of copolymers and block copolymers.Studies show that poly (L-alanine-co-hydroxypropyl-L-glutamine) random copolymer and block copolymer The same, with amphipathic, micelles can form in aqueous solution, but the size of the micelles is smaller than the block copolymer, the micelles morphology is not like the block copolymer is a regular sphere.Experiments found that, The proportion of the body has a great influence on the formation of micelles, micelles obtained by P (A10-co-HPG40) are the most uniform dispersion.The micelles formed by hydrophobic polyalanine as the core, hydrophilic polyhydroxyl Glutamine is the outer shell.