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本文为探索小儿如何合理应用狄戈辛。以幼狗分组分批口服狄戈辛后,用放射免疫法定期测定血清狄戈辛浓度,并观察反应及心电田改变。 共分“低维”,“高维”,“低饱”,“高饱”四组。“低维”与“高维”二组血清浓度高峰出现于3～6日,平衡后的血清浓度各为0.63±0.32ng/ml与0.67±0.07ng/ml,“低饱”与“高饱”二组血清浓度均在服药后二小时即达高峰,24小时内持续在高水平。第二天下降并相对稳定,血清浓度各为1.39±0.13及1.58±0.09ng/ml,少数标本高于3ng/ml,以“高饱”组略多。 根据各组实验结果分析讨论,并对小儿应用狄戈辛的剂量提出建议。
This article is to explore how to apply Digoxin in children. Serum Digoxin concentration was measured regularly by radioimmunoassay in groups of rabbits after oral administration of Digoxin, and the changes of response and electrocardiogram were observed. Divided into “low-dimensional”, “high-dimensional”, “low satiety”, “high satiety” four groups. Serum concentrations of “low dimensionality” and “high dimensionality” peaked at 3-6 days with the equilibrium serum concentrations of 0.63 ± 0.32ng / ml and 0.67 ± 0.07ng / ml, respectively. The “low satiety” and “high satiety” Serum concentrations of both groups reached their peak two hours after taking the drug and continued to be high within 24 hours. The next day decreased and relatively stable serum concentrations of 1.39 ± 0.13 and 1.58 ± 0.09ng / ml, a few samples higher than 3ng / ml, “high” group slightly more. According to the experimental results of each group analysis and discussion, and the application of pediatric doses of Digoxin recommendations.