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目的对代谢综合征(MS)人群在2年内发生心脑血管疾病的风险进行研究,为预防心脑血管疾病的发病提供依据。方法以北京某企业2006年在职及离退休人群的体检资料为基线,对所有55岁以上无冠心病、心肌梗死、脑梗死、脑出血等心脑血管疾病的2687例人群进行随访,至2008年出现临床确诊的这4种疾病的任何1种作为终点事件。MS采用中华医学会糖尿病分会的诊断标准。分析2年内MS人群心脑血管疾病的发生风险。结果 2年完成随访人群2067人,平均年龄(66.8±4.8)岁,MS人群发生心脑血管疾病的风险大于非MS人群,差异有统计学意义(P<0.05),前者的发病率(14.4%)是后者(7.1%)的2.020倍(95%CI:1.514～2.694)。随着MS异常组分聚集数的增加,心脑血管疾病的发病率呈上升趋势,2项以上(含2项)MS异常组分聚集人群其心脑血管疾病的发病风险是无异常组分人群的2.595～3.780倍。结论 MS异常组分的聚集增大了心脑血管疾病的发病风险。
Objective To study the risk of cardiovascular and cerebrovascular diseases in people with metabolic syndrome (MS) within 2 years and provide the basis for prevention of the occurrence of cardiovascular and cerebrovascular diseases. Methods Based on the physical examination data of a Beijing-based on-the-job and retired population in 2006, all 2687 patients with coronary heart disease, myocardial infarction, cerebral infarction, cerebral hemorrhage and other cardiovascular and cerebrovascular diseases over 55 years old were followed up till 2008 Any one of these 4 clinically diagnosed diseases appears as an end point. MS uses the Diabetes Branch of Chinese Medical Association diagnostic criteria. To analyze the risk of cardiovascular and cerebrovascular diseases in MS population within 2 years. Results There were 2067 follow-up patients (mean age 66.8 ± 4.8 years) at 2 years. The risk of cardiovascular and cerebrovascular diseases was higher in MS population than in non-MS population (P <0.05). The incidence of the former was 14.4% ) Was 2.020 times (95% CI: 1.514-2.694) of the latter (7.1%). The incidence of cardiovascular and cerebrovascular diseases is on the rise with the increase of the number of abnormal MS components. The risk of cardiovascular and cerebrovascular diseases in more than two (including two) MS abnormal components is the risk of cardiovascular disease without abnormalities Of 2.595 ~ 3.780 times. Conclusion Aggregation of abnormal MS components increases the risk of cardiovascular and cerebrovascular diseases.