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本文作者旨在①评价中等剂量氨甲喋呤、鞘内注射MTX治疗及头颅放射对存活2年以上的ALL小儿所致的N毒性;②探讨哪一项检查方法对发现化疗相关性N毒性损害最有价值。作者对存活2年以上的28例小儿ALL,按CNS预防性治疗方法不同而分组,对NS毒性损害进行研究,并以EEG、CT扫描、S-NS、IQ和EP等检查方法作为N毒性损害的评价指标。所见NS毒性损害表现有:异常脑电变化、轻度脑室扩张、矿化性微血管病、软N体征异常、IQ评分降低、VEP及BAEP异常。作者认为:CT扫描对
The aim of this study was to evaluate the N toxicity of ALL mid-dose methotrexate, intrathecal injection of MTX and cranial radiation in children with ALL who survived for more than 2 years. To explore which method was most valuable in detecting chemotherapy-related N toxicity . The author of 28 cases of children survived more than 2 years of ALL, according to CNS prophylactic treatment of different groups to study the toxicity of NS toxicity and EEG, CT scan, S-NS, IQ and EP as a method of N toxicity damage The evaluation index. The toxic manifestations of NS toxicity were abnormal EEG, mild ventricular dilatation, mineralized microangiopathy, abnormalities of soft N signs, decreased IQ scores, abnormalities of VEP and BAEP. The authors think: CT scan right