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本文报告了皮质类固醇隔日疗法治疗PNH取得满意疗效。作者采用强的松龙隔日60mg口服治疗19例PNH,至少3个月,结果8例取得良好疗效,3例有效,8例无效。疗效良好者治疗后1-7个月内(中位数2个月),Hb升至最高值,后将强的松龙渐减至维持量隔日20-40mg,能维持稳定的Hb值,但无一例Hb恢复正常。作者,对比有效与无效者发现,在性别、诊断时年龄、最初Hb、WBC及Ham试验阳性率等方面,无显著差异。治疗时年龄及治疗前病程,有效者均小于无效者,有显著差异,血与骨
This article reports the satisfactory results of corticosteroids every other day for the treatment of PNH. The authors treated prednisolone 60mg orally every other day 19 cases of PNH, at least 3 months, the results achieved good effect in 8 cases, 3 cases were effective, 8 cases of ineffective. Good effect within 1-7 months after treatment (median 2 months), Hb rose to the highest value, and then prednisolone decreased to maintain the next day 20-40mg, to maintain a stable Hb value, but None of the Hb returned to normal. The authors, compared with those found effective and ineffective, found no significant differences in gender, age at diagnosis, positive rates of initial Hb, WBC, and Ham tests. Treatment of age and course of treatment before treatment, were less effective than ineffective, there were significant differences in blood and bone