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作者将低剂量阿霉素(0.05mg/kg)包封在磁性微球中,以100倍高剂量的游离型阿霉素静脉注射(5mg/kg)作对照,用小白鼠尾为靶部位进行体内动力学研究。实验表明,在给药后60分钟,低剂量阿霉素磁性微球在靶部位保留时间约为游离型阿霉素二倍的浓度。以~(125)I标记微球,测定载体的体内分布。将鼠尾分为四段,第三段为靶部位暴露于强度为8000奥斯特(Oe)的磁场、梯度±4000 Oe。在鼠腹侧尾动脉注射微球5～60分钟内,肝、肺、脾仅有少量分布;心、肾和鼠尾1,
The authors encapsulated low-dose doxorubicin (0.05mg / kg) in magnetic microspheres, 100 times higher doses of free doxorubicin intravenously (5mg / kg) as a control, with the mouse tail as the target site In vivo kinetics studies. Experiments show that 60 minutes after administration, low-dose doxorubicin magnetic microspheres in the target site retention time is about twice the concentration of free-type doxorubicin. The microspheres were labeled with ~ (125) I and the in vivo distribution of the vector was determined. The tail was divided into four sections, the third section was the target site exposed to a magnetic field of intensity 8000 Oe, gradient ± 4000 Oe. In the rat ventral caudal artery injection of microspheres 5 to 60 minutes, liver, lung, spleen only a small amount of distribution; heart, kidney and rat tail 1,