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作者以改良琼脂平板双倍稀释方程法研究了两种新β-内酰胺酶抑制剂——6-β-溴青霉烷酸(6-B)和6-β-碘青霉烷酸(6-Ⅰ)及另外两种β-内酰胺酶抑制剂——克拉维酸(Clavulanic acid)和青霉烷砜(Sulbactam, CP-45,899)的单独抗菌活性以及分别与氨苄青霉素联合的抗菌活性。接种菌量为10~3cfu(菌落形成单位)和10~6 cfu,氨苄青霉素浓度为0.08～128mg/l与β-内酰胺酶抑制剂0.5、2、8、32mg/l联合。氨苄青霉素单独及联合最低抑菌浓度为使菌量减少99.9%的浓度。实验结果表明,克拉维酸的抗菌活性为酶抑制剂中最强者,全部肠杆菌和金葡萄可
The authors studied the effects of two new β-lactamase inhibitors, 6-β-bromo penicillanate (6-B) and 6-β-iodopenicillanic acid -Ⅰ) and the other two β-lactamase inhibitors, Clavulanic acid and Sulbactam (CP-45,899), as well as antibacterial activity in combination with ampicillin respectively. Inoculation amount of 10 ~ 3cfu (colony forming units) and 10 ~ 6 cfu, ampicillin concentration of 0.08 ~ 128mg / l and β-lactamase inhibitor 0.5,2,8,32mg / l joint. Ampicillin alone and in combination with the minimum inhibitory concentration of bacteria to make 99.9% of the concentration. The experimental results show that the antibacterial activity of clavulanic acid inhibitor for the strongest, all Enterobacter and gold grape may