论文部分内容阅读
吗啡及某些内源性阿片样物质降低血压、减慢心率的作用部分是因激活延髓阿片受体,减低交感张力而产生。激活同脑区内α-肾上腺素能受体的抗高血压药氯压定(Clonidine)具有同吗啡作用相似的作用(如降低血压、减慢心率、镇痛等)。氯压定停药产生的症状与阿片戒断症状相似,阻滞氯压定与中枢α-受体交互作用的药物育亨宾、哌氧环烷亦能引起类似阿片戒断的症状,而氯压定可逆转阿片成瘾者的戒断症状。这些相似性说明,中枢阿片受体与α-受体系统之间存在着某种交互作用。作者等最近报道,纳洛酮抑制氯压定和α-甲基多巴对自发性高血压大鼠的降压作用,但不能拮抗
Morphine and certain endogenous opioids reduce blood pressure, slowing down the role of heart rate is due in part to the activation of medullary opiate receptors, reducing the sympathetic tone and produce. Clonidine, an antihypertensive drug that activates alpha-adrenergic receptors in the brain, has similar effects as morphine (lowering blood pressure, slowing heart rate, relieving pain, etc.). Clonidine Clopidogrel produces similar symptoms as opiate withdrawal symptoms. Yohimbin and Piroxicam, which block the interaction of clonidine and central α-receptor, can also cause symptoms similar to opiate withdrawal. Chlorine Prescription can reverse withdrawal symptoms of opiate addicts. These similarities suggest that there is some interaction between the central opioid receptor and the alpha-receptor system. The authors recently reported that naloxone inhibits the antihypertensive effects of clonidine and alpha-methyl dopa in spontaneously hypertensive rats but can not antagonize