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目的观察脂代谢紊乱与CRP水平变化对2型糖尿病(T2DM)合并冠心病(CHD)患者的影响。方法 98例健康体检者为对照组(A组),85例经临床确诊T2DM患者为B组,以及55例经临床确诊T2DM合并CHD患者为C组,采用全自动生化分析仪检测血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoA1/ApoB、HDL-C/LDL-C、HDL-C/TC浓度;采用免疫比浊法测定血清CRP水平。结果与A组比较,B组、C组TG、TC、LDL-C、ApoB、CRP水平明显升高,HDL-C、ApoA1、ApoA1/ApoB、HDL-C/LDL-C、HDL-C/TC浓度明显降低;与B组比较,C组患者TG、TC、LDL-C、ApoB、CRP水平明显升高。结论 T2DM合并CHD患者与单纯T2DM患者脂质代谢发生紊乱,血清TG、TC、LDL-C、ApoB、CRP水平明显升高,HDL-C、ApoA1、ApoA1/ApoB、HDL-C/LDL-C、HDL-C/TC浓度明显降低;早期诊断及时治疗与预后密切相关,诊治过程中应控制脂代谢紊乱与CRP水平变化,有助于提高治疗效果,改善预后,防止或延缓并发症发生。
Objective To investigate the effects of lipid metabolism disorders and CRP levels on type 2 diabetes mellitus (T2DM) patients with coronary heart disease (CHD). Methods A total of 98 healthy subjects were selected as control group (A group), 85 patients with clinically confirmed T2DM as group B, and 55 patients with clinically confirmed T2DM complicated with CHD as group C. Serum triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), serum apolipoprotein A1 (ApoA1), apolipoprotein B / ApoB, HDL-C / LDL-C, and HDL-C / TC concentration respectively. Serum CRP levels were measured by immunoturbidimetry. Results Compared with group A, the levels of TG, TC, LDL-C, ApoB and CRP in group B and group C were significantly higher than those in group A. HDL-C, ApoA1, ApoA1 / ApoB, HDL-C / Compared with group B, the levels of TG, TC, LDL-C, ApoB and CRP in group C were significantly increased. Conclusions The levels of TG, TC, LDL-C, ApoB and CRP in patients with T2DM complicated with CHD and those with simple T2DM were significantly lower than those in patients with T2DM alone. The levels of HDL-C, ApoA1, ApoA1 / ApoB, HDL- HDL-C / TC concentration significantly reduced; early diagnosis and timely treatment and prognosis are closely related to the diagnosis and treatment of lipid metabolism disorders and CRP levels should be controlled to help improve the treatment effect, improve prognosis and prevent or delay the occurrence of complications.