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【答】Shy-Drager综合征义称多系统变性,是以下述临床表现为主的一种神经综合征,包括直立性低血压,性欲减退或阳萎,尿失禁或尿潴留,无汗及Homer征等随物神经症状,以及全身乏力、肌萎缩、肌束震颤、运动性共济失调、肌张力增高、动作减少等运动系症状,伴随运动消失、失张力性步态和言语不清、Babinski征(+),是由Shy和Drager于1960年首先报告的。1969年Grahman和Oppenimer提出了多系统萎缩症的新概念,并将其归类为Shy-Drager综合征(SDS)、纹状体黑质变性和橄榄桥脑小脑萎缩等3种病症。
[A] Shy-Drager syndrome is a multi-system degeneration that is characterized by the clinical manifestations of orthostatic hypotension, loss of libido or impotence, incontinence or urinary retention, no sweat, and Homer Signs such as neurological symptoms, as well as generalized muscle weakness, muscle atrophy, fasciculation, motor ataxia, increased muscle tension, decreased motor activity and other symptoms, accompanied by loss of exercise, loss of gait and gaffe, Babinski Sign (+) was first reported by Shy and Drager in 1960. In 1969, Grahman and Oppenimer proposed a new concept of multiple system atrophy and classified them as Shy-Drager syndrome (SDS), striatonigral degeneration and olivopontocerebellar atrophy.