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目的探讨硝苯地平控释片联合甲基多巴治疗妊娠高血压综合征(PIH)的临床效果。方法将PIH患者80例随机分为两组,每组40例。对照组单用硝苯地平控释片口服,观察组在对照组基础上加用甲基多巴口服,均以7 d为1个疗程,治疗2个疗程。结果治疗后两组患者血压均下降,且观察组较对照组明显下降(P<0.05);两组患者24 h尿蛋白均下降,观察组为(1.31±0.11)g,较对照组的(2.11±0.27)g明显下降(P<0.05);观察组胎盘早剥、产后出血、新生儿呼吸窘迫、新生儿死亡发生率均较对照组明显下降(P<0.05);观察组临床总有效率为92.50%,明显高于对照组的77.50%(P<0.05)。结论硝苯地平控释片联合甲基多巴能明显降低PIH的血压,改善妊娠结局。
Objective To investigate the clinical effect of nifedipine controlled release tablets combined with methyl-dopa in the treatment of pregnancy-induced hypertension (PIH). Methods 80 patients with PIH were randomly divided into two groups, 40 cases in each group. Control group was nifedipine controlled release tablets orally, the observation group on the basis of the control group plus methyldopa oral, both 7 d for a course of treatment for 2 courses. Results After treatment, the blood pressure of both groups decreased, and the observation group was significantly lower than that of the control group (P <0.05). The urinary protein in 24 hours in both groups decreased (1.31 ± 0.11) g, ± 0.27) g (P <0.05). The incidences of placental abruption, postpartum hemorrhage, neonatal respiratory distress and neonatal death in the observation group were significantly lower than those in the control group (P <0.05). The total effective rate in the observation group was 92.50%, which was significantly higher than that of the control group (77.50%, P <0.05). Conclusion Nifedipine controlled release tablets combined with methyldopa can significantly reduce the blood pressure of PIH and improve pregnancy outcomes.