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目的 为了解内皮素（ Ｅ Ｔ） 是否与高血压病（ Ｅ Ｈ） 及其靶器官受损有联系。方法 分析了５４例不同分期 Ｅ Ｈ 和２７ 例对照血浆 Ｅ Ｔ。结果 Ｅ Ｈ 组血浆 Ｅ Ｔ 水平较对照组增高，差异显著（ Ｐ＜ ０ ．０１） 。而在 Ｅ Ｈ 各分期组中，Ⅰ期（２８ 例） 与对照组血浆 Ｅ Ｔ 水平相近，差异不显著（ Ｐ＞ ０ ．０５） ；Ⅱ期（１１ 例） 和Ⅲ期（１５例） 分别较对照组和Ⅰ期患者明显增高，差异非常显著（ Ｐ＜ ０ ．０１） 。１５ 例超声心动图诊断左室肥厚者和１１例心电图、 Ｘ 线诊断心脏肥厚、扩大者与无肥厚扩大者比较，血浆 Ｅ Ｔ 差异显著（ Ｐ＜ ０ ．０１） 。７ 例心功能不全和５ 例肾损害者分别与心、肾功能正常者比较血浆 Ｅ Ｔ 水平明显升高，差异显著（ Ｐ＜ ０ ．０１ ， Ｐ＜ ０ ．０５） 。血压增高的程度、病程、年龄均与 Ｅ Ｔ 浓度不相关。结论 血浆 Ｅ Ｔ 增高与 Ｅ Ｈ 靶器官损害、功能障碍有联系。
Objective To understand whether endothelin (ET) is associated with hypertension and its target organ damage. Methods 54 cases of different stages of E H and 27 cases of control plasma E T. Results The level of plasma E T in EH group was significantly higher than that in control group (P <0.01). However, the levels of plasma E T in stage Ⅰ (28 cases) and control group were similar (P> 0.05), but in stage Ⅱ (11 cases) and stage Ⅲ (15 cases), respectively The control group and stage Ⅰ patients were significantly higher, the difference was significant (P <0 .01). Echocardiography diagnosed left ventricular hypertrophy in 15 patients and 11 cases of electrocardiogram, X-ray diagnosis of cardiac hypertrophy, enlargement and no enlargement compared with plasma E T significant difference (P <0.01). Seven patients with cardiac insufficiency and 5 patients with renal impairment were significantly higher than those with normal heart and kidney function, the plasma E T levels were significantly increased (P <0.01, P <0.05). The degree of hypertension, course of disease, age and E T concentration are not related. Conclusions The increase of plasma E T is related to the target organ damage and dysfunction of EH.