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本文对糠醛的毒性进行了较系统的研究。糠醛属中等毒性化学物,大鼠腹腔注入LD_(50)=132.8mg/kg,小鼠为190mg/kg。在体内蓄积系数大于5,蓄积作用很小。机体不产生耐受性。它是染色体断裂剂,有诱变作用。能引起小鼠精母细胞SCE强阳性反应,诱发小鼠精子畸形率显著增加,有遗传损伤毒性作用。大鼠致畸试验证明主要引起胎鼠
In this paper, furfural toxicity was systematically studied. Furfural is a moderate toxic chemicals, intraperitoneal injection of LD_ (50) = 132.8mg / kg, mice 190mg / kg. Accumulation coefficient in the body is greater than 5, the accumulation of small. The body does not produce tolerance. It is a chromosomal cleavage agent, mutagenic effect. Can cause strong positive SCE in mouse spermatocytes response, induced a significant increase in sperm deformity in mice, genetic damage toxicity. Teratogenicity test in rats shows that the main cause fetal mice