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目的探讨小剂量环孢菌素A联合雄激素治疗再生障碍性贫血的临床疗效。方法46例再生障碍性贫血的患者随机分为观察组和对照组,对照组用雄激素治疗,观察组在对照组治疗的基础上加用小剂量环孢菌素(CsA)3 mg/(kg.d),口服。疗程至少3个月,如无效停用,有效再继续服用3～6个月减量、停药并随访观察。结果两组患者经治疗后总有效率观察组为86.9%,对照组为65.2%,两组比较有统计学意义(P<0.05)。观察组治疗前后血象的变化经比较差异有统计学意义(P<0.05)。结论环孢菌素A联合雄激素治疗再生障碍性贫血是有效的治疗方案,其不但安全可靠,且不良反应少,值得临床推广应用。
Objective To investigate the clinical efficacy of low-dose cyclosporin A combined with androgen in the treatment of aplastic anemia. Methods A total of 46 patients with aplastic anemia were randomly divided into observation group and control group. The control group was treated with androgen. The observation group was treated with CsA 3 mg / (kg) .d), orally. Treatment at least 3 months, such as invalid disable, effective and then continue to take 3 to 6 months reduction, withdrawal and follow-up observation. Results The total effective rate of the two groups after treatment was 86.9% in the observation group and 65.2% in the control group, with statistical significance (P <0.05). The observation group before and after treatment of blood changes after the difference was statistically significant (P <0.05). Conclusion Cyclosporine A combined with androgen therapy for aplastic anemia is an effective treatment, which is not only safe and reliable, but also has few side effects and is worthy of clinical application.