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目的:应用核糖核酸(RNA)对慢性肝炎、肝硬化进行抗肝纤维化治疗,以改善肝脏组织学指标,恢复肝功能。方法:用RNA治疗慢性肝炎、肝硬化83例,与辅酶Q_(10)治疗的43例对照,疗程3个月。结果:RNA提高血清白蛋白、降低血清谷丙转氨酶(ALT)及血清透明质酸(HA)含量的疗效明显优于对照组。治疗前后2次肝活检光镜和电镜检查对比观察,RNA治疗后肝脏炎症、坏死程度和胶原纤维定量所反映的肝纤维化程度均明显减轻,对照组则无变化,其纤维化程度反而加重。统计学上两组有明显差异。临床与病理结果一致。结论:RNA确有保护肝细胞和抗肝纤维化作用。
Objective: To apply RNA to treat chronic hepatitis and liver cirrhosis against liver fibrosis to improve the liver histological index and restore the liver function. Methods: 83 cases of chronic hepatitis and liver cirrhosis were treated with RNA and 43 cases were treated with coenzyme Q_ (10) for 3 months. Results: The therapeutic effect of RNA on serum albumin, serum ALT and serum hyaluronic acid (HA) was significantly better than that of the control group. Two liver biopsies before and after treatment were observed by light microscopy and electron microscopy. Liver inflammation, necrosis and collagen fibrosis quantitatively reflected the degree of hepatic fibrosis after RNA treatment was significantly reduced, while the control group had no change, but the degree of fibrosis increased. Statistically significant difference between the two groups. Clinical and pathological findings. Conclusion: RNA does protect liver cells and prevent hepatic fibrosis.